2026-06-29T02:50:06Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/180202023-07-17T19:27:39Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Acaz Fonseca, Estefanía author Ortiz Rodriguez, Ana author López Rodríguez, Ana Belén author García Segura, Luis Miguel author Astiz, Mariana 2023-06-17T22:04:29Z 2023-06-17T22:04:29Z 2017-03-06 2045-2322 10.1038/srep43878 https://hdl.handle.net/20.500.14352/18020 https://www.nature.com/srep/ Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC) of male and female mice during early postnatal life, when sex steroids induce sex-dimorphic maturation of the brain. Despite the fact that total amount of CL was similar, its fatty acid composition differed between males and females at birth. In males, CL was more mature (lower saturation ratio) and the expression of the enzymes involved in synthetic and remodeling pathways was higher, compared to females. Importantly, the sex differences found in CL metabolism were due to the testosterone peak that male mice experience perinatally. These changes were associated with a higher expression of UCP-2 and its activators in the CC of males. Overall, our results suggest that the perinatal testosterone surge in male mice regulates CL biosynthesis and remodeling in the CC, inducing a sex-dimorphic fatty acid composition. In male’s CC, CL is more susceptible to peroxidation, likely explaining the testosterone-dependent induction of neuroprotective molecules such as UCP-2. These differences may account for the sex-dependent mitochondrial susceptibility after perinatal hypoxia/ischemia. eng Atribución 3.0 España Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria journal article URL https://docta.ucm.es/bitstreams/da5d8bab-42e8-4e56-a590-5f0bf1f0fab0/download File MD5 2181a9e9215fe5b28e77d2f87d7e7330 1169137 application/pdf Astiz. 2017. Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria.pdf URL https://docta.ucm.es/bitstreams/f769a004-eb5a-4fa7-9023-5b8745697145/download File MD5 d8eb9743d8bbccf38ace4156d08925ef 59940 text/plain Astiz. 2017. Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria.pdf.txt