2026-07-18T13:10:04Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/230772024-04-16T18:35:06Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Martínez Carmona, Marina author Colilla Nieto, Montserrat author Vallet Regí, María Dulce Nombre 2023-06-18T05:41:51Z 2023-06-18T05:41:51Z 2015-12 2079-4991 10.3390/nano5041906 https://hdl.handle.net/20.500.14352/23077 http://www.mdpi.com/ The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, transport and protect drug molecules until the target is reached. It is possible to incorporate different targeting ligands to the outermost surface of MSNs to selectively drive the drugs to the tumour tissues. To prevent the premature release of the cargo entrapped in the mesopores, it is feasible to cap the pore entrances using stimuli-responsive nanogates. Therefore, upon exposure to internal (pH, enzymes, glutathione, etc.) or external (temperature, light, magnetic field, etc.) stimuli, the pore opening takes place and the release of the entrapped cargo occurs. These smart MSNs are capable of selectively reaching and accumulating at the target tissue and releasing the entrapped drug in a specific and controlled fashion, constituting a promising alternative to conventional chemotherapy, which is typically associated with undesired side effects. In this review, we overview the recent advances reported by the scientific community in developing MSNs for antitumor therapy. We highlight the possibility to design multifunctional nanosystems using different therapeutic approaches aimed at increasing the efficacy of the antitumor treatment. eng Atribución 3.0 España Smart Mesoporous Nanomaterials for Antitumor Therapy journal article URL https://docta.ucm.es/bitstreams/b5183c85-d3d3-4512-b8b7-b3613cfc933c/download File MD5 2bb116a8d452e9d992c00f834c02c718 1652324 application/pdf 637 Nanomaterials. 5, 1906-1937 (2015).-OPEN ACCESS MONTSE.pdf URL https://docta.ucm.es/bitstreams/4f9dc0f0-f459-4c74-b3a0-f66c884b2d42/download File MD5 8b6d6a7d936d889e059b43bc6d90a593 100361 text/plain 637 Nanomaterials. 5, 1906-1937 (2015).-OPEN ACCESS MONTSE.pdf.txt