2026-06-27T10:48:29Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/233812023-08-28T05:50:23Zcom_20.500.14352_14col_20.500.14352_15

Muñoz Sáez, Emma Munck García, Estefanía de Arahuetes Portero, Rosa María Vicente, Francisca Ortiz López, Francisco Javier Cantizani, Juan Gómez Miguel, Begoña 2023-06-18T05:48:25Z 2023-06-18T05:48:25Z 2015-04-23 0304-3940 10.1016/j.neulet.2015.03.010 https://hdl.handle.net/20.500.14352/23381 https://www.journals.elsevier.com/neuroscience-letters/ Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA. eng restricted access Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y) journal article