2026-06-27T11:04:07Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/238962023-08-28T12:08:51Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Tejero, Jesús author Jimenez López, Pilar author Quinto, Emiliano author Córdoba Díaz, Damián author Garrosa, Manuel author Córdoba Díaz, Manuel author Gayoso, Manuel author Girbés Juan, Tomás 2023-06-18T06:06:39Z 2023-06-18T06:06:39Z 2015-01-30 1420-3049 10.3390/molecules20022364 https://hdl.handle.net/20.500.14352/23896 https://doi.org/10.3390/molecules20022364 https://www.mdpi.com/1420-3049/20/2/2364 Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses. eng Atribución-NoComercial 3.0 España Elderberries: A Source of Ribosome-Inactivating Proteins with Lectin Activity journal article URL https://docta.ucm.es/bitstreams/4a2d144a-34ea-484f-b758-d05c5a63f9f9/download File MD5 c750cfdd40241c7384547054f01746db 2203161 application/pdf molecules-20-02364.pdf URL https://docta.ucm.es/bitstreams/3fa25d48-c9ea-4d2b-8557-19202432cdfc/download File MD5 a874edd1c6954d5b53314914f0e8998a 76573 text/plain molecules-20-02364.pdf.txt