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oai:docta.ucm.es:20.500.14352/239282023-08-25T10:44:36Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Garrosa, Manuel author Jimenez López, Pilar author Tejero, Jesús author Cabrero, Patricia author Córdoba Díaz, Damián author Quinto, Emiliano author Gayoso, Manuel author Girbés Juan, Tomás author 2015-02-02 All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level. 2072-6651 10.3390/toxins7020367 https://hdl.handle.net/20.500.14352/23928 https://doi.org/10.3390/toxins7020367 Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice