2026-06-07T13:54:16Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/240912024-07-05T14:36:21Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
García Martín, Elena Salobrar
author
Hoyas, Irene
author
Leal, Mercedes
author
Hoz Montañana, María Rosa De
author
Rojas López, María Blanca
author
Ramírez Sebastián, Ana Isabel
author
Salazar Corral, Juan José
author
Yubero Pancorbo, Raquel
author
Gil Gregorio, Pedro
author
Triviño Casado, Alberto
author
Ramírez Sebastián, José Manuel
2023-06-18T06:45:57Z
2023-06-18T06:45:57Z
2015-06-08
2314-6133; 2314-6141 (-e)
Article ID 636548
https://hdl.handle.net/20.500.14352/24091
http://www.hindawi.com/journals/bmri/aa/636548/
Decreased thickness of the retinal nerve fiber layer (RNFL) may reflect retinal neuronal-ganglion cell death. A decrease in the RNFL has been demonstrated in Alzheimer’s disease (AD) in addition to aging by optical coherence tomography (OCT). Twenty-three mild-AD patients and 28 age-matched control subjects with mean Mini-Mental State Examination 23.3 and 28.2, respectively, with no ocular disease or systemic disorders affecting vision, were considered for study. OCT peripapillary and macular segmentation thickness were examined in the right eye of each patient. Compared to controls, eyes of patients with mild-AD patients showed no statistical difference in peripapillary RNFL thickness (P>0.05); however, sectors 2, 3, 4, 8, 9, and 11 of the papilla showed thinning, while in sectors 1, 5, 6, 7, and 10 there was thickening. Total macular volume and RNFL thickness of the fovea in all four inner quadrants and in the outer temporal quadrants proved to be significantly decreased (P<0.01). Despite the fact that peripapillary RNFL thickness did not statistically differ in comparison to control eyes, the increase in peripapillary thickness in our mild-AD patients could correspond to an early neurodegeneration stage and may entail the existence of an inflammatory process that could lead to progressive peripapillary fiber damage.
eng
Atribución 3.0 España
Analysis of Retinal Peripapillary Segmentation in Early Alzheimer’s Disease Patients
journal article
URL
https://docta.ucm.es/bitstreams/5e40b207-627d-47ad-ac27-8b4b461483ba/download
File
MD5
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application/pdf
Retinal peripallilary alzheimer_2015.pdf
URL
https://docta.ucm.es/bitstreams/47de271b-3199-43aa-8d6a-e65d05b4e613/download
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MD5
dfec9c1f10ad7bfe98fa47d2b3c1c590
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text/plain
Retinal peripallilary alzheimer_2015.pdf.txt