2026-06-27T10:30:04Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/246682023-08-11T07:16:21Zcom_20.500.14352_14col_20.500.14352_15

Rodríguez, Irene Novais, Ângela Lira, Felipe Valverde, Aránzazu Curião, Tânia Martínez, José Luis Baquero, Fernando Cantón, Rafael Coque, Teresa M 2023-06-18T06:57:28Z 2023-06-18T06:57:28Z 2015-05 1098-6596 10.1128/AAC.00296-15 https://hdl.handle.net/20.500.14352/24668 http://aac.asm.org/content/59/5/2904 We describe the genetic background of bla(TEM-4) and the complete sequence of pRYC11::bla(TEM-4), a mosaic plasmid that is highly similar to pKpQIL-like variants, predominant among TEM-4 producers in a Spanish hospital (1990 to 2004), which belong to Klebsiella pneumoniae and Escherichia coli high-risk clones responsible for the current spread of different antibiotic resistance genes. Predominant populations of plasmids and host adapted clonal lineages seem to have greatly contributed to the spread of resistance to extended-spectrum cephalosporins. eng restricted access Antibiotic-resistant Klebsiella pneumoniae and Escherichia coli high-risk clones and an IncFII(k) mosaic plasmid hosting Tn1 (blaTEM-4) in isolates from 1990 to 2004 journal article