2026-06-27T23:01:48Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/246982024-06-21T16:57:12Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Ronzoni, Giacomo author Antón, María author Mora Teruel, Francisco author Segovia Camargo, Gregorio author Arco González, Alberto Del 2023-06-18T06:58:19Z 2023-06-18T06:58:19Z 2016-01 0166-4328 10.1016/j.bbr.2015.10.037 https://hdl.handle.net/20.500.14352/24698 http://www.journals.elsevier.com/behavioural-brain-research http://www.sciencedirect.com/science/article/pii/S0166432815302515 The aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABAA antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone. These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories. eng Infralimbic cortex controls the activity of the hypothalamus-pituitary adrenal axis and the formation of aversive memory: effects of environmental enrichment journal article URL https://docta.ucm.es/bitstreams/cd89f3b6-174a-44ea-986f-dc616b7360ea/download File MD5 ccd7507db2038ac772f1f88ffe45296b 237515 application/pdf BehavBrainRes E-print.pdf URL https://docta.ucm.es/bitstreams/c452ff1d-18a1-4e5b-bc69-32bd523fe612/download File MD5 d838b4742d3cd739b8d85a8641e466cc 39197 text/plain BehavBrainRes E-print.pdf.txt