2026-06-27T16:07:50Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/352642023-08-11T07:16:17Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Drumo, Rosanna author Pesciaroli, Michele author Ruggeri, Jessica author Tarantino, Michela author Chirullo, Barbara author Pistoia, Claudia author Petrucci, Paola author Martinelli, Nicola author Moscati, Livia author Manuali, Elisabetta author Pavone, Silvia author Picciolini, Matteo author Ammendola, Serena author Gabai, Gianfranco author Battistoni, Andrea author Pezzotti, Giovanni author Alborali, Giovanni L author Napolioni, Valerio author Pasquali, Paolo author Magistrali, Chiara F 2023-06-19T15:04:16Z 2023-06-19T15:04:16Z 2015 2235-2988 https://hdl.handle.net/20.500.14352/35264 https://doi.org/10.3389/fcimb.2015.00106 Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota. eng Atribución 3.0 España Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota journal article URL https://docta.ucm.es/bitstreams/24e96e6b-7dbc-4afc-853f-e47378168132/download File MD5 123885e746d478ad24116d0379df560d 3198238 application/pdf 807.pdf URL https://docta.ucm.es/bitstreams/0cd6d123-7a57-4eae-b517-5b622aa8c160/download File MD5 5fd2d955218138a722a72568968017ed 59424 text/plain 807.pdf.txt