2026-06-08T02:40:23Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/382572023-09-12T07:54:35Zcom_20.500.14352_14col_20.500.14352_22
Docta Complutense
advisor
Torres Suárez, Ana Isabel
author
Martín Sabroso, Cristina
2023-06-19T16:58:22Z
2023-06-19T16:58:22Z
2014-03-27
https://hdl.handle.net/20.500.14352/38257
Glucocorticoids (GCs) and dexamethasone play a central role in the treatment of lymphoid malignancies, particularly acute lymphoblastic leukaemia (ALL). Preclinical
studies have shown that GCs also affect cell differentiation, proliferation and apoptosis of osteosarcoma cells, hepatoma cells, mammary tumor cells, glioma cells, melanoma cells and thyroid cancer cells. The proliferation and apoptotic effects of GCs are cell type-specific as well as time and concentration dependent. In spite of the high effectiveness of dexamethasone treatment in ALL, mainly in children, GC resistance occurs in 10-30% of untreated patients, being more frequent in T-lineage than B-precursor acute lymphoblastic leukaemia. Furthermore, systemic administration of high doses of dexamethasone are required for inducing tumor cell apoptosis but causes severe side effects such as osteoporosis, Cushing's syndrome or an increased risk of infections. Even though most combined chemotherapy protocols currently used in clinics include dexamethasone at high doses, recent clinical investigations on the eficacy of dexamethasone in refractory multiple myeloma have shown synergic effects of low doses of this GC combined with pomalidomide or lenalidomide...
spa
Desarrollo de micropartículas de dexametasona como estrategia para aumentar la eficacia de los esquemas de poliquimioterapia
doctoral thesis
URL
https://docta.ucm.es/bitstreams/ecbd4469-8a34-490e-b302-3ccbc3826dce/download
File
MD5
b955544a7ab393b1105f029e1a5a9898
4501685
application/pdf
T35265.pdf