2026-06-27T16:04:44Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/451542024-07-04T15:36:25Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Carracedo Rodríguez, Juan Gonzalo
author
Peral Cerda, María Asunción
author
Pintor Just, Jesús Jerónimo
2023-06-20T04:18:37Z
2023-06-20T04:18:37Z
2010-11
Carracedo Rodríguez, G., Peral Cerda, M. A., Pintor Just, J. J. «Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients». Investigative Opthalmology & Visual Science, vol. 51, n.o 11, noviembre de 2010, p. 5452. DOI.org (Crossref), https://doi.org/10.1167/iovs.09-5088.
0146-0404
10.1167/iovs.09-5088
https://hdl.handle.net/20.500.14352/45154
http://dx.doi.org/10.1167/iovs.09-5088
http://iovs.arvojournals.org/article.aspx?articleid=2126238&resultClick=1
Purpose.: To analyze the levels of diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) in tears of subjects with Sjögren syndrome and to compare them with those in a control group.
Methods.: Twelve subjects with a diagnosis of Sjögren syndrome and 20 healthy control subjects were invited to participate in the present study. Schirmer strips were used to measure tear secretion (Schirmer I test) and to collect tears. Ap4A and Ap5A were measured by high-pressure liquid chromatography (HPLC), and a dry eye questionnaire (DEQ) was used to evaluate dry eye symptomatology.
Results.: The mean concentrations of Ap4A and Ap5A in the Sjögren syndrome group were 2.54 ± 1.02 and 26.13 ± 6.95 μM, respectively. This group of patients was divided in two subgroups: four patients with normal tear production and eight patients with low tear production. Concentrations of Ap4A, and Ap5A in patients with normal tear production (Schirmer test result, 12.3 ± 1.2 mm) were 0.47 ± 0.20 and 8.03 ± 3.27 μM, respectively. In the patients with low tear production (Schirmer test result, 1.0 ± 0.3 mm), the concentrations were 4.09 ± 1.36 and 39.51 ± 8.46 μM, respectively and in the control group, 0.13 ± 0.03 and 0.04 ± 0.02 μM, respectively.
Conclusions.: Patients with Sjögren syndrome have abnormally elevated concentrations of diadenosine polyphosphates, indicating that these compounds could be used in the diagnosis of this disease.
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Atribución-NoComercial-SinDerivadas 3.0 España
Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients
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