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oai:docta.ucm.es:20.500.14352/452082024-07-04T16:27:39Zcom_20.500.14352_14col_20.500.14352_15

Puell Marín, María Cinta Barrio De Santos, Ana Rosa Palomo Álvarez, Catalina Gómez Sanz, Fernando J. Clement Corral, Amaya Pérez Carrasco, María Jesús 2023-06-20T04:21:42Z 2023-06-20T04:21:42Z 2012 Puell Marín, M. C., Barrio De Santos, A. R., Palomo Álvarez, C. et al. «Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration». Investigative Opthalmology & Visual Science, vol. 53, n.o 11, octubre de 2012, p. 7310. DOI.org (Crossref), https://doi.org/10.1167/iovs.11-8649. 0146-0404 10.1167/iovs.11-8649 https://hdl.handle.net/20.500.14352/45208 https//doi.org/10.1167/iovs.11-8649 http://iovs.arvojournals.org/article.aspx?articleid=2127992 Purpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD. eng https://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration journal article