2026-09-30T23:37:08Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/452082024-07-04T16:27:39Zcom_20.500.14352_14col_20.500.14352_15

Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration Puell Marín, María Cinta Barrio De Santos, Ana Rosa Palomo Álvarez, Catalina Gómez Sanz, Fernando J. Clement Corral, Amaya Pérez Carrasco, María Jesús 617.7 617.75 Mediated multifocal electroretinogram Geographic Atrphy Dark-Adaptation Maculopathy Vision Contrast Luminance Chart Classification Dysfunction Oftalmología Optometría 3201.09 Oftalmología 2209.15 Optometría Abierto en la web del editor Purpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD. Fundación Investigación Médica Mutua Madrileña Banco Santander-Universidad Complutense de Madrid Depto. de Optometría y Visión Fac. de Óptica y Optometría TRUE pub 2023-06-20T04:21:42Z 2023-06-20T04:21:42Z 2012 journal article https://hdl.handle.net/20.500.14352/45208 0146-0404 10.1167/iovs.11-8649 eng FMM-02538/2008 GR 58/08 Puell Marín, M. C., Barrio De Santos, A. R., Palomo Álvarez, C. et al. «Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration». Investigative Opthalmology & Visual Science, vol. 53, n.o 11, octubre de 2012, p. 7310. DOI.org (Crossref), https://doi.org/10.1167/iovs.11-8649. Atribución-NoComercial-SinDerivadas 3.0 España https://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access application/pdf The Association for Research in Vision and Ophthalmology, Inc.