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00925njm 22002777a 4500 dc Gómez-Carpintero Jiménez, Jorge author Sánchez Cebrián, Juan Domingo author González Matilla, Juan Francisco author Menéndez Ramos, José Carlos author 2021-10-01 Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug. Gómez-Carpintero Jiménez, J., Sánchez Cebrián, J. D., González Matilla, J. F. & Menéndez Ramos, J. C. «Mechanochemical Synthesis of Primary Amides». The Journal of Organic Chemistry, vol. 86, n.o 20, octubre de 2021, pp. 14232-37. DOI.org (Crossref), https://doi.org/10.1021/acs.joc.1c02350. 0022-3263 10.1021/acs.joc.1c02350 https://hdl.handle.net/20.500.14352/4599 https://doi.org/10.1021/acs.joc.1c02350 https://pubs.acs.org/doi/abs/10.1021/acs.joc.1c02350 Mechanochemical Synthesis of Primary Amides