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Docta Complutense author Prieto Montero, Ruth author Prieto Castañeda, Alejandro author Katsumiti, Alberto author Sola Llano, Rebeca author Rodríguez Agarrabeitia, Antonia author Cajaraville, Miren P. author Ortiz García, María Josefa author Martínez Martínez, Virginia 2023-06-16T14:18:21Z 2023-06-16T14:18:21Z 2021-12-04 Prieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Red haloBODIPYs as Theragnostic Agents: The Role of the Substitution at Meso Position». Dyes and Pigments, vol. 198, febrero de 2022, p. 110015. DOI.org (Crossref), https://doi.org/10.1016/j.dyepig.2021.110015. 0143-7208 10.1016/j.dyepig.2021.110015 https://hdl.handle.net/20.500.14352/4603 https://doi.org/10.1016/j.dyepig.2021.110015 Three different molecular designs based on BODIPY dye have been proposed as photosensitizers (PSs) for photodynamic therapy (PDT) by the inclusion of halogen atoms (Iodine) at 2,6-positions and with extended conjugation at 3, 5-positions and varying the substitution at meso position. The synthesis is described and their main photophysical features including singlet oxygen production and triplet states were characterized by absorption and fluorescence spectroscopy (steady-state and time-correlated) and nanosecond transient absorption spectroscopy. The results were compared with the commercial Chlorin e6. The three new red-halogen-BODIPYs showed a great balance between singlet oxygen generation (ΦΔ≥0.40) and fluorescence (Φfl≥0.22) for potential application on PDT, and particularly in theragnosis. In vitro experiments in HeLa cells were done to study their performance and to elucidate the best potential candidate for PDT. eng Atribución-NoComercial-SinDerivadas 3.0 España Red haloBODIPYs as theragnostic agents: The role of the substitution at meso position journal article URL https://docta.ucm.es/bitstreams/72d63164-cef7-4a2d-b6db-ffc7fbed5886/download File MD5 4d797ada1be4c8641bdafc36ea6b5d22 2255165 application/pdf 1-s2.0-S0143720821008810-main.pdf URL https://docta.ucm.es/bitstreams/5516bb3a-7797-49b3-b6d1-a27cdea8da33/download File MD5 b455c3cb8dc52992c40384abf6daa100 67192 text/plain 1-s2.0-S0143720821008810-main.pdf.txt