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oai:docta.ucm.es:20.500.14352/46752024-01-27T21:04:46Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Almendro Vedia, Víctor Galileo author Natale, Paolo author Valdivieso González, David author Lillo, M. Pilar author Aragones, Juan L. author López-Montero, Iván author 2021-09-15 F1Fo-ATP synthase (ATP synthase) is a central membrane protein that synthetizes most of the ATP in the cell through a rotational movement driven by a proton gradient across the hosting membrane. In mitochondria, ATP synthases can form dimers through specific interactions between some subunits of the protein. The dimeric form of ATP synthase provides the protein with a spontaneous curvature that sustain their arrangement at the rim of the high-curvature edges of mitochondrial membrane (cristae). Also, a direct interaction with cardiolipin, a lipid present in the inner mitochondrial membrane, induces the dimerization of ATP synthase molecules along cristae. The deletion of those biochemical interactions abolishes the protein dimerization producing an altered mitochondrial function and morphology. Mechanically, membrane bending is one of the key deformation modes by which mitochondrial membranes can be shaped. In particular, bending rigidity and spontaneous curvature are important physical factors for membrane remodelling. Here, we discuss a complementary mechanism whereby the rotatory movement of the ATP synthase might modify the mechanical properties of lipid bilayers and contribute to the formation and regulation of the membrane invaginations. 0003-9861 10.1016/j.abb.2021.108939 https://hdl.handle.net/20.500.14352/4675 https://doi.org/10.1016/j.abb.2021.108939 How rotating ATP synthases can modulate membrane structure