2026-06-07T19:38:51Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/47182024-09-24T13:44:06Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Ghosh, Ritwik author Dubey, Souvik author Ray, Adrija author Roy, Dipayan author De, Kaustav author Mandal, Arpan author Naga, Dinobandhu author Swaika, Bikash Chandra author Pandit, Alak author Benito León, Julián 2023-06-16T14:20:01Z 2023-06-16T14:20:01Z 2021-07-16 Ghosh R, Dubey S, Ray A, Roy D, De K, Mandal A, et al. Wernicke’s encephalopathy precipitated by neuromyelitis optica spectrum disorder and Graves’ disease: A tale of clinical and radiological dilemmas. Clinical & Exp Neuroim 2022;13:67–71. https://doi.org/10.1111/cen3.12661. 1759-1961 10.1111/cen3.12661 https://hdl.handle.net/20.500.14352/4718 https://doi.org/10.1111/cen3.12661 Background Neuromyelitis optica spectrum disorder (NMOSD), an autoimmune astrocytopathy, may share common clinico-radiological features with Wernicke's encephalopathy (WE). A variant of NMOSD, known as area postrema syndrome (APS), that presents with intractable hiccups and associated vomiting, might lead to the depletion of nutrients if not detected and treated early. Autoimmune thyroid disorders (i.e., Graves’ disease) may be associated with NMOSD. Rarely, thyrotoxicosis can give rise to thiamine depletion and WE. Case presentation Here, we present a case of untreated hyperthyroidism in an Indian female who presented with thyrotoxicosis and later developed WE, possibly also contributed by NMOSD (APS)-induced recurrent vomiting. The patient recovered with antithyroid drugs, parenteral thiamine, and immunomodulatory therapy. The possible pathogenic mechanisms have been discussed. Conclusion Our case establishes the importance of considering NMOSD variants in metabolic encephalopathy, especially if neuroimaging is suggestive and in the backdrop of another autoimmune disorder. eng Atribución-NoComercial 3.0 España Wernicke’s encephalopathy precipitated by neuromyelitis optica spectrum disorder and Graves’ disease: A tale of clinical and radiological dilemmas journal article URL https://docta.ucm.es/bitstreams/b0ce65d6-098b-4322-9cf6-1e4ea49101ee/download File MD5 2899ca4ddffa8706c0c2675a426f109c 711774 application/pdf Clinical Exp Neuroim - 2021 - Ghosh - Wernicke s encephalopathy precipitated by neuromyelitis optica spectrum disorder.pdf URL https://docta.ucm.es/bitstreams/235db844-cf39-42d8-bc93-ce203fa80303/download File MD5 b889a2df8c7471d8a69b6c5af76b1fef 24830 text/plain Clinical Exp Neuroim - 2021 - Ghosh - Wernicke s encephalopathy precipitated by neuromyelitis optica spectrum disorder.pdf.txt