2026-06-27T22:48:01Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/47842025-09-15T14:22:10Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Gorfinkiel, Nicole author Martínez Arias, Alfonso author 2021 Over the last few years an intense activity in the areas of advanced microscopy and quantitative cell biology has put the focus on the morphogenetic events that shape embryos. The interest in these processes is taking place against the backdrop of genomic studies, particularly of global patterns of gene expression at the level of single cells, which cannot fully account for the way cells build tissues and organs. Here we discuss the need to integrate the activity of genes with that of cells and propose the need to develop a framework, based on cellular processes and cell interactions, that parallels that which has been created for gene activity in the form of Gene Regulatory Networks (GRNs). We begin to do this by suggesting elements for building Cell Regulatory Networks (CRNs). In the same manner that GRNs create schedules of gene expression that result in the emergence of cell fates over time, CRNs create tissues and organs i.e. space. We also suggest how GRNs and CRNs might interact in the building of embryos through feedback loops involving mechanics and tissue tectonics. 2667-2901 10.1016/j.cdev.2021.203720 https://hdl.handle.net/20.500.14352/4784 https://doi.org/10.1016/j.cdev.2021.203720 https://www.sciencedirect.com/science/article/pii/S2667290121000541?via%3Dihub The cell in the age of the genomic revolution: Cell Regulatory Networks