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00925njm 22002777a 4500 dc Díez Villanueva, Pablo author García Acuña, Jose María author Raposeiras Roubin, Sergio author Barrabés, Jose A. author Cordero, Alberto author Bardají, Alfredo author Martínez-Sellés D Oliveira Soares, Manuel author Marín, Francisco author Ruiz Nodar, Juan M. author Vicente Ibarra, Nuria author Alonso Salinas, Gonzalo L. author Cid Alvárez, Belén author Abu Assi, Emad author Formiga, Frances author Núñez, Julio author Núñez, Eduardo author Ariza Solé, Albert author Sanchis, Juan author 2021-09-26 Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. 2077-0383 10.3390/jcm10194403 https://hdl.handle.net/20.500.14352/4796 https://doi.org/10.3390/jcm10194403 https://www.mdpi.com/2077-0383/10/19/4403/htm Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome