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oai:docta.ucm.es:20.500.14352/48312024-10-11T14:20:13Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Méndez Bailón, Manuel author Iguarán Bermúdez, Rosario author López García, Lidia author Sánchez Sauce, Beatriz author Pérez Mateos, Pablo author Barrado Cuchillo, Julia author Villar Martínez, Miguel author Fernández Castelao, Santiago author García Klepzig, José Luis author Fuentes Ferrer, Manuel author García García, Alejandra author Vila Costa, Isidro author Miguel Yanes, José María De author Casas Rojo, José author Calvo Manuel, Elpidio author Andrès, Emmanuel author Lorenzo Villalba, Noel author 2021-10-23 Background and Objectives: The prevalence and incidence of heart failure (HF) have been increasing in recent years as the population ages. These patients show a distinct profile of comorbidity, which makes their care more complex. In recent years, the PROFUND index, a specific tool for estimating the mortality rate at one year in pluripathology patients, has been developed. The aim of this study was to evaluate the prognostic value of the PROFUND index and of in-hospital and 30-day mortality after discharge of patients admitted for acute heart failure (AHF). Materials and Methods: A prospective multicenter longitudinal study was performed that included patients admitted with AHF and ≥2 comorbid conditions. Clinical, analytical, and prognostic variables were collected. The PROFUND index was collected in all patients and rates of in-hospital and 30-day mortality after discharge were analyzed. A bivariate analysis was performed with quantitative variables between patients who died and those who survived at the 30-day follow-up. A logistic regression analysis was performed with the variables that obtained statistical significance in the bivariate analysis between deceased and surviving subjects. Results: A total of 128 patients were included. Mean age was 80.5 +/− 9.98 years, and women represented 51.6%. The mean PROFUND index was 5.26 +/− 4.5. The mortality rate was 8.6% in-hospital and 20.3% at 30 days. Preserved left ventricular ejection fraction was found in 60.9%. In the sample studied, there were patients with a PROFUND score < 7 predominated (89 patients (70%) versus 39 patients (31%) with a PROFUND score ≥ 7). Thirteen patients (15%) with a PROFUND score < 7 died versus the 13 (33%) with a PROFUND score ≥ 7, p = 0.03. Twelve patients (15%) with a PROFUND score < 7 required readmission versus 12 patients (35%) with a PROFUND score ≥ 7, p = 0.02. The ROC curve of the PROFUND index for in-hospital mortality and 30-day follow-up in patients with AHF showed AUC 0.63, CI: 95% (0.508–0.764), p <0.033. Conclusions: The PROFUND index is a clinical tool that may be useful for predicting short-term mortality in elderly patients with AHF. Further studies with larger simple sizes are required to validate these results. Méndez Bailón, M., Iguarán Bermúdez, R., López García, L. et al. «Prognostic Value of the PROFUND Index for 30-Day Mortality in Acute Heart Failure». Medicina, vol. 57, n.o 11, octubre de 2021, p. 1150. Crossref, https://doi.org/10.3390/medicina57111150. 1648-9144 10.3390/medicina57111150 https://hdl.handle.net/20.500.14352/4831 https://doi.org/10.3390/medicina57111150 https://www.mdpi.com/1648-9144/57/11/1150/htm Prognostic Value of the PROFUND Index for 30-Day Mortality in Acute Heart Failure