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oai:docta.ucm.es:20.500.14352/48362023-07-13T05:26:45Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Pascual Antón, Lucía author Cardeñes, Beatriz author Sainz de la Cuesta, Ricardo author González Cortijo, Lucía author López Cabrera, Manuel author Cabañas, Carlos author Sandoval, Pilar author 2021-10-25 Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peritoneal mesothelial cell (PMC) monolayer that lines the abdominal cavity is the first barrier encountered by OvCA cells. Subsequent progression of tumors through the peritoneum leads to the accumulation into the peritoneal stroma of a sizeable population of carcinoma-associated fibroblasts (CAFs), which is mainly originated from a mesothelial-to-mesenchymal transition (MMT) process. A common characteristic of OvCA patients is the intraperitoneal accumulation of ascitic fluid, which is composed of cytokines, chemokines, growth factors, miRNAs, and proteins contained in exosomes, as well as tumor and mesothelial suspended cells, among other components that vary in proportion between patients. Exosomes are small extracellular vesicles that have been shown to mediate peritoneal metastasis by educating a pre-metastatic niche, promoting the accumulation of CAFs via MMT, and inducing tumor growth and chemoresistance. This review summarizes and discusses the pivotal role of exosomes and MMT as mediators of OvCA peritoneal colonization and as emerging diagnostic and therapeutic targets. 1422-0067 10.3390/ijms222111496 https://hdl.handle.net/20.500.14352/4836 https://doi.org/10.3390/ijms222111496 https://www.mdpi.com/1422-0067/22/21/11496/htm Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer