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Docta Complutense author González Hedström, Daniel author Fuente Fernández, María De La author Priego Cuadra, Teresa author Martín Velasco, Ana Isabel author Amor, Sara author López-Calderón Barreda, Asunción author Inarejos García, Antonio Manuel author García Villalón, Ángel Luís author Granado, Miriam 2023-06-16T14:22:42Z 2023-06-16T14:22:42Z 2021-07-01 González Hedström, D., Fuente Fernández, M., Priego Cuadra, T. et al. «Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats». Antioxidants, vol. 10, n.o 7, julio de 2021, p. 1066. DOI.org (Crossref), https://doi.org/10.3390/antiox10071066. 2076-3921 10.3390/antiox10071066 https://hdl.handle.net/20.500.14352/4871 https://doi.org/10.3390/antiox10071066 https://www.mdpi.com/2076-3921/10/7/1066/htm Olive-derived products, such as virgin olive oil (EVOO) and/or olive leaf extracts (OLE), exert anti-inflammatory, insulin-sensitizing and antihypertensive properties and may be useful for stabilizing omega 3 fatty acids (n-3 PUFA) due to their high content in antioxidant compounds. In this study, the addition of OLE 4:0.15 (w/w) to a mixture of algae oil (AO) rich in n-3 PUFA and EVOO (25:75, w/w) prevents peroxides formation after 12 months of storage at 30 °C. Furthermore, the treatment with the oil mixture (2.5 mL/Kg) and OLE (100 mg/Kg) to 24 month old Wistar rats for 21 days improved the lipid profile, increased the HOMA-IR and decreased the serum levels of miRNAs 21 and 146a. Treatment with this new nutraceutical also prevented age-induced insulin resistance in the liver, gastrocnemius and visceral adipose tissue by decreasing the mRNA levels of inflammatory and oxidative stress markers. Oil mixture + OLE also attenuated the age-induced alterations in vascular function and prevented muscle loss by decreasing the expression of sarcopenia-related markers. In conclusion, treatment with a new nutraceutical based on a mixture of EVOO, AO and OLE is a useful strategy for improving the stability of n-3 PUFA in the final product and to attenuate the cardiometabolic and muscular disorders associated with aging. eng Atribución 3.0 España Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats journal article URL https://docta.ucm.es/bitstreams/52ea7c3a-5bea-4a86-9cea-13fe6a7ad308/download File MD5 2d12f6a6399a9d68669f24ec64a14df1 11924992 application/pdf antioxidants-10-01066-v4.pdf