2026-06-28T04:45:38Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/49342023-08-27T11:12:31Zcom_20.500.14352_14col_20.500.14352_15
Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients
Fuso, Paola
Di Salvatore, Mariantonietta
Santonocito, Concetta
Guarino, Donatella
Autilio, Chiara
Mulè, Antonino
Arciuolo, Damiano
Rinninella, Antonina
Mignone, Flavio
Ramundo, Matteo
Di Stefano, Brunella
Orlandi, Armando
Capoluongo, Ettore
Nicolotti, Nicola
Franceschini, Gianluca
Martín Sánchez, Alejandro
Tortora, Giampaolo
Scambia, Giovanni
Barone, Carlo
Cassano, Alessandra
Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC).
Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system.
Results: Event-free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let-7a-5p (EFS p = 0.006; OS p = 0.0001), mirR-100-5p (EFS s p = 0.01; OS p = 0.03), miR-101-3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer.
2023-06-16T14:24:00Z
2023-06-16T14:24:00Z
2023-06-16T14:24:00Z
2021-08-20
journal article
https://hdl.handle.net/20.500.14352/4934
2075-4426
10.3390/jpm11080816
eng
https://creativecommons.org/licenses/by/3.0/es/
open access
Atribución 3.0 España
MPDI