2026-08-22T00:37:02Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/503802024-06-07T16:09:01Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Reche Gallardo, Pedro Antonio
author
Keskin, Derin B
author
Hussey, Rebecca E
author
Ancuta, Petronela
author
Gabuzda, Dana
author
Reinherz, Ellis L
2023-06-20T09:48:05Z
2023-06-20T09:48:05Z
2006
1476-9433
10.1186/1476-9433-5-1
https://hdl.handle.net/20.500.14352/50380
http://www.medimmunol.com/content/5/1/1
Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNgamma producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects.
eng
Atribución 3.0 España
Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes
journal article
URL
https://docta.ucm.es/bitstreams/d07cfae9-7054-4c62-a106-c97d7ef64e71/download
File
MD5
d3a9c9622e05babd4b606e35a82e3bb0
673945
application/pdf
31.Reche_etal_MI_2006.pdf
URL
https://docta.ucm.es/bitstreams/07a813c7-b26c-4697-a949-cd746b7cefc7/download
File
MD5
20e539420231110bf3359a72efcfe50c
74983
text/plain
31.Reche_etal_MI_2006.pdf.txt