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oai:docta.ucm.es:20.500.14352/503802024-06-07T16:09:01Zcom_20.500.14352_14col_20.500.14352_15

Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes Reche Gallardo, Pedro Antonio Keskin, Derin B Hussey, Rebecca E Ancuta, Petronela Gabuzda, Dana Reinherz, Ellis L 612.017 57:004 Inmunología Microbiología (Biología) Biología molecular (Biología) Bioinformática 2412 Inmunología 2414 Microbiología 2415 Biología Molecular Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNgamma producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects. Depto. de Inmunología, Oftalmología y ORL Fac. de Medicina TRUE pub 2023-06-20T09:48:05Z 2023-06-20T09:48:05Z 2006 journal article https://hdl.handle.net/20.500.14352/50380 1476-9433 10.1186/1476-9433-5-1 eng Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ open access application/pdf BioMed Central