2026-06-08T03:25:35Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/62352024-04-16T17:34:48Zcom_20.500.14352_14col_20.500.14352_15

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules. Castillo, Rafael R. Lozano Borregón, Daniel Vallet Regí, María Dulce Nombre 543 615.46 Mesoporous silica Therapeutic biomolecules Proteins Peptides Nucleic acids Glycans Materiales Química inorgánica (Farmacia) 3312 Tecnología de Materiales RESEARCHER ID L-2854-2014 (Rafael Castillo Romero) ORCID 0000-0003-1957-3098 (Rafael Castillo Romero) RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón) ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very dièerent nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials. Unión Europea. Horizonte 2020 Depto. de Química en Ciencias Farmacéuticas Fac. de Farmacia TRUE pub 2023-06-16T15:17:49Z 2023-06-16T15:17:49Z 2020-05-07 journal article https://hdl.handle.net/20.500.14352/6235 1999-4923 10.3390/pharmaceutics12050432 eng VERDI (694160) Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ open access application/pdf MDPI