2026-06-27T15:48:26Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/62862024-10-11T14:31:20Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Torres, Sandra
author
Abdullah, Zeinab
author
Brol, Maximilian J.
author
Hellerbrand, Claus
author
Fernández, Mercedes
author
Fiorotto, Romina
author
Klein, Sabine
author
Königshofer, Philipp
author
Liedtke, Christian
author
Lotersztajn, Sophie
author
Nevzorova, Yulia
author
Schierwagen, Robert
author
Reiberger, Thomas
author
Uschner, Frank Erhard
author
Tacke, Frank
author
Weiskirchen, Ralf
author
Trebicka, Jonel
2023-06-16T15:18:30Z
2023-06-16T15:18:30Z
2020-03-16
1661-6596, ESSN: 1422-0067
10.3390/ijms21062027
https://hdl.handle.net/20.500.14352/6286
https://www.mdpi.com/1422-0067/21/6/2027
Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany.
eng
Atribución 3.0 España
Recent advances in practical methods for liver cell biology: a short overview
journal article
URL
https://docta.ucm.es/bitstreams/8fe4d50c-c6d0-4678-af0a-974eb529caae/download
File
MD5
a512494ace7911661eaae984e616f222
1253365
application/pdf
Torres, Sandra et al. 2020. Recent advances in practical methods....pdf