2026-06-28T04:47:25Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/63812023-08-28T12:12:06Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Wanelik, Klara M.
author
Begon, Mike
author
Arriero Higueras, Elena
author
Bradley, Janette E.
author
Friberg, Ida M.
author
Jackson, Joseph A.
author
Taylor, Christopher H.
author
Paterson, Steve
2023-06-16T15:19:58Z
2023-06-16T15:19:58Z
2020-05-04
2045-2322
10.1038/s41598-020-64307-7
https://hdl.handle.net/20.500.14352/6381
https://www.nature.com/articles/s41598-020-64307-7
Individuals vary in their immune response and, as a result, some are more susceptible to infectious disease than others. Little is known about the nature of this individual variation in natural populations, or which components of immune pathways are most responsible, but defning this underlying landscape of variation is an essential frst step to understanding the drivers of this variation and, ultimately, predicting the outcome of infection. We describe transcriptome-wide variation in response to a standardised immune challenge in wild feld voles. We fnd that genes (hereafter 'markers') can be categorised into a limited number of types. For the majority of markers, the response of an individual is dependent on its baseline expression level, with signifcant enrichment in this category for conventional immune pathways. Another, moderately sized, category contains markers for which the responses of diferent individuals are also variable but independent of their baseline expression levels. This category lacks any enrichment for conventional immune pathways. We further identify markers which display particularly high individual variability in response, and could be used as markers of immune response in larger studies. Our work shows how a standardised challenge performed on a natural population can reveal the patterns of natural variation in immune response.
eng
Atribución 3.0 España
Transcriptome-wide analysis reveals diferent categories of
response to a standardised immune challenge in a wild rodent
journal article
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Wanelik, Klara M. 2020. Transcriptome-wide analysis reveals different categories.....pdf
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Wanelik, Klara M. 2020. Transcriptome-wide analysis reveals different categories.....pdf.txt