2026-06-27T22:59:46Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/64092024-07-16T09:03:25Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Pérez García, Selene author Carrión Caballo, Mar author Gutiérrez Cañas, Irene author Villanueva Romero, Raúl author Castro Vázquez, David author Martínez Mora, María Del Carmen author González-Álvaro, Isidoro author Blanco, Francisco J. author Juarranz Moratilla, Yasmina author Pérez Gomáriz, Rosa María author 2019-12-22 The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs. 2073-4409 10.3390/cells9010040 https://hdl.handle.net/20.500.14352/6409 https://doi.org/10.3390/cells9010040 Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin