2026-06-27T12:39:08Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/65212023-08-26T15:19:13Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
García Villaluenga, Juan Pedro
author
Vidal, Jules
author
Cao García, Francisco Javier
2023-06-16T15:22:35Z
2023-06-16T15:22:35Z
2020-07-20
1539-3755
10.1103/PhysRevE.102.012407
https://hdl.handle.net/20.500.14352/6521
https://doi.org/10.1103/PhysRevE.102.012407
https://journals.aps.org/
Ligand binding to polymers modifies the physical and chemical properties of the polymers, leading to physical, chemical, and biological implications. McGhee and von Hippel obtained the equilibrium coverage as a function of the ligand affinity, through the computation of the possible binding sites for the ligand. Here, we complete this theory deriving the kinetic model for the ligand-binding dynamics and the associated equilibrium chemical potential, which turns out to be of the Tonks gas model type. At low coverage, the Tonks chemical potential becomes the Fermi chemical potential and even the ideal gas chemical potential. We also discuss kinetic models associated with these chemical potentials. These results clarify the kinetic models of ligand binding, their relations with the chemical potentials, and their range of validity. Our results highlight the inaccuracy of ideal and simplified kinetic approaches for medium and high coverages.
eng
Noncooperative thermodynamics and kinetic models of ligand binding to polymers: Connecting McGhee-von Hippel model with the Tonks gas model
journal article
URL
https://docta.ucm.es/bitstreams/0ae0c069-c596-4838-abef-ee0299a14ea6/download
File
MD5
f43b3fb00ae93b50910a88dafdd4fe0e
786476
application/pdf
Villaluenga43libre.pdf