2026-06-08T05:59:08Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/65452025-09-15T14:27:20Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Navas-Olive, Andrea author Valero, Manuel author Jurado-Parras, Teresa author Salas-Quiroga, Adán de author Averkin, Robert G. author Gambino, Giuditta author Cid, Elena author Liset, M. de la Prida 2023-06-16T15:23:11Z 2023-06-16T15:23:11Z 2020 2041-1723 10.1038/s41467-020-15840-6 https://hdl.handle.net/20.500.14352/6545 https://doi.org/10.1038/s41467-020-15840-6 Theta oscillations play a major role in temporarily defining the hippocampal rate code by translating behavioral sequences into neuronal representations. However, mechanisms constraining phase timing and cell-type-specific phase preference are unknown. Here, we employ computational models tuned with evolutionary algorithms to evaluate phase preference of individual CA1 pyramidal cells recorded in mice and rats not engaged in any particular memory task. We applied unbiased and hypothesis-free approaches to identify effects of intrinsic and synaptic factors, as well as cell morphology, in determining phase preference. We found that perisomatic inhibition delivered by complementary populations of basket cells interacts with input pathways to shape phase-locked specificity of deep and superficial pyramidal cells. Somatodendritic integration of fluctuating glutamatergic inputs defined cycle-by-cycle by unsupervised methods demonstrated that firing selection is tuneable across sublayers. Our data identify different mechanisms of phase-locking selectivity that are instrumental for flexible dynamical representations of theta sequences. eng Atribución 3.0 España Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations journal article URL https://docta.ucm.es/bitstreams/1f6d4cf3-9590-4919-aab1-a00202dc4c38/download File MD5 8e4838e6ca48fa9a5c317d9bb8034e5e 2906790 application/pdf Navas Olive, Andrea et al. 2020. Multimodals determinants of phase-locked.....pdf