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Docta Complutense author Simancas Herbada, Rebeca author Fernández Carballido, Ana María author Aparicio Blanco, Juan author Slowing Barillas, Karla Verónica author Rubio Retama, Benito Jorge author López Cabarcos, Enrique author Torres Suárez, Ana Isabel 2023-06-17T08:21:50Z 2023-06-17T08:21:50Z 2020-02-19 Simancas Herbada, R., Fernández Carballido, A. M., Aparicio Blanco, J. et al. «Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets». Pharmaceutics, vol. 12, n.o 2, febrero de 2020, p. 174. DOI.org (Crossref), https://doi.org/10.3390/pharmaceutics12020174. 1999-4923 10.3390/pharmaceutics12020174 https://hdl.handle.net/20.500.14352/6756 https://doi.org/10.3390/pharmaceutics12020174 The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two di_erent crosslinking degrees that were characterized by FTIR and DSC. Their acute oral toxicity was determined in a mouse model, showing no toxicity at doses up to 10 g/kg. Matrix tablets were prepared using metformin hydrochloride as a model drug and the mechanisms involved in drug release (swelling and/or erosion) were investigated using biorrelevant media. This new hydrogel e_ectively controlled the release of small and highly hydrophilic molecules as metformin, when formulated in matrix tablets for oral administration. The rate of metformin release from PAMgA matrices was mainly controlled by its di_usion through the gel layer (Fickian di_usion). The swelling capacity and the erosion of the matrix tablets influenced the metformin release rate, that was slower at pH 6.8, where polymer swelling is more intensive, than in gastric medium, where matrix erosion is slightly more rapid. The crosslinking degree of the polymer significantly influenced its swelling capacity in acid pH, where swelling is moderate, but not in intestinal fluid, where swelling is more intense. eng Attribution 4.0 International Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets journal article URL https://docta.ucm.es/bitstreams/7a07741a-dc6c-4321-891d-233d62046e67/download File MD5 cb6a412dbbc3e649fd665bfab5a0bc76 1354638 application/pdf pharmaceutics-12-00174.pdf