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00925njm 22002777a 4500 dc Palacios Ceña, Domingo author Florencio, Lidiane Lima author Hernández Barrera, Valentín author Fernández de las Peñas, César author Miguel Díez, Javier De author Martínez Hernández, David author Carabantes Alarcón, David author Jiménez García, Rodrigo author López De Andrés, Ana Isabel author López Herranz, Marta author 2021 Background: To assess time trends in the incidence and in-hospital outcomes of urinary tract infection (UTI) in older people (≥65 years) in Spain (2001–2018) according to sex and to identify the factors independently associated with in-hospital mortality (IHM). Methods: Using the Spanish National Hospital Database, we analyzed comorbidity, procedures, diagnosis, isolated microorganisms, and outcomes. Results: We included 583,693 admissions (56.76% women). In both sexes, the incidence increased with age over time (p < 0.001). In men and women, the highest IHM was found among the oldest patients (>84 years) with values of 9.16% and 8.6%, respectively. The prevalence of bacteremia increased from 4.61% to 4.98% from 2001 to 2018 (p < 0.001) and sepsis decreased from 3.16% to 1.69% (p < 0.001). The risk of dying increased with age (>84 years) (OR 3.63; 95% CI 3.5–3.78) and with almost all comorbidities. Urinary catheter was a risk factor for women (OR 1.1; 95% CI 1.02–1.18) and protective for men (OR 0.71; 95% CI 0.66–0.76). Isolation of Staphylococcus aureus increased the risk of IHM by 40% among men (OR 1.4; 95% CI 1.28–1.53). After adjusting for confounders, IHM decreased over time. Conclusions: The incidence of UTIs was higher in older patients and increased over time; however, IHM decreased during the same period. Female sex, age, comorbidities, sepsis, and a Staphylococcus aureus isolation increased risk of IHM. Palacios Ceña, DD., Florencio, L. L., Hernández Barrera, V. et al. «Trends in Incidence and Outcomes of Hospitalizations for Urinary Tract Infection among Older People in Spain (2001–2018)». Journal of Clinical Medicine, vol. 10, n.o 11, mayo de 2021, p. 2332. https://doi.org/10.3390/jcm10112332. 2077-0383 10.3390/jcm10112332 https://hdl.handle.net/20.500.14352/6973 https://doi.org/10.3390/jcm10112332 https://www.mdpi.com/2077-0383/10/11/2332/htm Trends in Incidence and Outcomes of Hospitalizations for Urinary Tract Infection among Older People in Spain (2001–2018)