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00925njm 22002777a 4500 dc Gómez Pinedo, Ulises author García Ávila, Yolanda author Gallego Villarejo, Lucía author Matias-Guiu Antem, Jordi author Benito Martín, María Soledad author Esteban García, Noelia author Sanclemente Alamán, Inmaculada author Pytel, Vanesa author Moreno Jiménez, Lidia author Sancho Bielsa, Francisco author Vidorreta Ballesteros, Lucía author Montero Escribano, Paloma author Matías-Guiu Guía, Jorge author 2021-05-14 Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. Material and Methods: We included three groups—a group of patients with AQP4–IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines. Results and Conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative. Gómez Pinedo, U., García Ávila, Y., Gallego Villarejo, L. et al. «Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System». International Journal of Molecular Sciences, vol. 22, n.o 10, mayo de 2021, p. 5192. DOI.org (Crossref), https://doi.org/10.3390/ijms22105192. 1422-0067 10.3390/ijms22105192 https://hdl.handle.net/20.500.14352/7051 https://doi.org/10.3390/ijms22105192 https://www.mdpi.com/1422-0067/22/10/5192/htm Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System