2026-06-27T12:39:19Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/70802023-08-27T14:15:32Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Vega Martín, Elena author Gil Ortega, Marta author González Blázquez, Raquel author Benedito Castellote, Sara author Fernández Felipe, Jesús author Ruiz Gayo, Mariano author Olmo, Nuria del author Chowen, Julie A. author Frago, Laura M. author Somoza, Beatriz author Fernández Alfonso, María Soledad 2023-06-17T08:25:44Z 2023-06-17T08:25:44Z 2021-03-19 2072-6643 10.3390/nu13031003 https://hdl.handle.net/20.500.14352/7080 https://doi.org/10.3390/nu13031003 https://www.mdpi.com/journal/nutrients Vegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high-oleic-acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans-fats in the food industry. The aim of this study is to analyze the impact of SFA and MUFA-enriched high-fat (HF) diets on endothelial function, vascular remodeling, and arterial stiffness compared to commercial HF diets. Five-week-old male C57BL6J mice were fed a standard (SD), a HF diet enriched with SFA (saturated oil-enriched Food, SOLF), a HF diet enriched with MUFA (unsaturated oil-enriched Food, UOLF), or a commercial HF diet for 8 weeks. Vascular function was analyzed in the thoracic aorta. Structural and mechanical parameters were assessed in mesenteric arteries by pressure myography. SOLF, UOLF, and HF diet reduced contractile responses to phenylephrine and induced endothelial dysfunction in the thoracic aorta. A significant increase in the β-index, and thus in arterial stiffness, was also detected in mesenteric arteries from the three HF groups, due to enhanced deposition of collagen in the vascular wall. SOLF also induced hypotrophic inward remodeling. In conclusion, these data demonstrate a deleterious effect of HF feeding on obesity-related vascular alterations that is exacerbated by SFA. eng Atribución 3.0 España Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice journal article URL https://docta.ucm.es/bitstreams/63156d57-f7c4-4ac1-b4b6-83c56ecc238b/download File MD5 365da8767967c7874146402c6d28b2f1 23291171 application/pdf nutrients-13-01003-v2.pdf