2026-06-08T11:05:08Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/71312023-08-26T06:40:44Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Galindo Izquierdo, María author Pablos Álvarez, José Luis author 2021-01-13 The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target. 2073-4409 10.3390/cells10010148 https://hdl.handle.net/20.500.14352/7131 https://doi.org/10.3390/cells10010148 https://www.mdpi.com/2073-4409/10/1/148/htm Complement as a Therapeutic Target in Systemic Autoimmune Diseases