2026-06-08T12:21:41Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/71312023-08-26T06:40:44Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Galindo Izquierdo, María
author
Pablos Álvarez, José Luis
2023-06-17T08:26:37Z
2023-06-17T08:26:37Z
2021-01-13
2073-4409
10.3390/cells10010148
https://hdl.handle.net/20.500.14352/7131
https://doi.org/10.3390/cells10010148
https://www.mdpi.com/2073-4409/10/1/148/htm
The complement system (CS) includes more than 50 proteins and its main function is to recognize and protect against foreign or damaged molecular components. Other homeostatic functions of CS are the elimination of apoptotic debris, neurological development, and the control of adaptive immune responses. Pathological activation plays prominent roles in the pathogenesis of most autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, rheumatoid arthritis, dermatomyositis, and ANCA-associated vasculitis. In this review, we will review the main rheumatologic autoimmune processes in which complement plays a pathogenic role and its potential relevance as a therapeutic target.
eng
Atribución 3.0 España
Complement as a Therapeutic Target in Systemic Autoimmune Diseases
journal article
URL
https://docta.ucm.es/bitstreams/21653e68-3624-45ab-a12b-1880dda0ee3d/download
File
MD5
4b9153bcd64fa51c5899c22fc1ea3651
740182
application/pdf
cells-10-00148-v3.pdf