2026-06-29T08:02:26Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/713242024-09-19T13:40:02Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Fernández Lucas, Alberto Amable author Vaquero Zamora, Lucía author Bajo Bretón, Ricardo author Zuluaga Arias, María del Pilar 2023-06-22T10:40:41Z 2023-06-22T10:40:41Z 2022 Fernández Lucas, A. A., Vaquero Zamora, L., Bajo Bretón, R. et al. «Apolipoprotein E Ɛ4–Related Effects on Cognition Are Limited to the Alzheimer’s Disease Spectrum». GeroScience, vol. 44, n.o 1, febrero de 2022, pp. 195-209. DOI.org (Crossref), https://doi.org/10.1007/s11357-021-00450-x. 2509-2715 10.1007/s11357-021-00450-x https://hdl.handle.net/20.500.14352/71324 2509-2723 https://doi.org/10.1007/s11357-021-00450-x Whether the deleterious efects of APOE4 are restricted to the Alzheimer’s disease (AD) spectrum or cause cognitive impairment irrespectively of the development of AD is still a matter of debate, and the focus of this study. Our analyses included APOE4 genotype, neuropsychological variables, amyloid-βeta (Aβ) and Tau markers, FDG-PET values, and hippocampal volumetry data derived from the healthy controls sample of the ADNI database. We formed 4 groups of equal size (n=30) based on APOE4 carriage and amyloid-PET status. Baseline and followup (i.e., 48 months post-baseline) results indicated that Aβ-positivity was the most important factor to explain poorer cognitive performance, while APOE4 only exerted a signifcant efect in Aβ-positive subjects. Additionally, multiple regression analyses evidenced that, within the Aβ-positive sample, hippocampal volumetry explained most of the variability in cognitive performance for APOE4 carriers. These fndings represent a strong support for the so-called preclinical/prodromal hypothesis, which states that the reported diferences in cognitive performance between healthy carriers and non-carriers are mainly due to the APOE4’s capability to increase the risk of AD. Moreover, our results reinforce the notion that a synergistic interaction of Aβ and APOE4 elicits a neurodegenerative process in the hippocampus that might be the main cause of impaired cognitive performance. eng Atribución 3.0 España Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum journal article URL https://docta.ucm.es/bitstreams/743e81db-f77a-4eb9-90c8-859811282a0b/download File MD5 16ef0468489f3ca881804ea516b95e85 1572511 application/pdf Fernández2022_Article_ApolipoproteinEƐ4RelatedEffect.pdf URL https://docta.ucm.es/bitstreams/c479780e-c28a-4587-b631-745043316593/download File MD5 5a4426c30500e751d2e0172f2d79ab98 70421 text/plain Fernández2022_Article_ApolipoproteinEƐ4RelatedEffect.pdf.txt