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00925njm 22002777a 4500 dc Bhayani, Raj author Martínez De La Casa Fernández-Borrella, José María author Figus, Michele author Klabe, Karsten author Rabiolo, Alessandro author Mercieca, Karl author 2022-03-12 To evaluate 1-year success rates and safety profile of Preserflo™ Microshunt in glaucoma patients.Retrospective multicentre cohort study of 100 consecutive eyes (91 patients) from four tertiary-referral glaucoma centres. Four intraocular pressure (IOP) criteria were defined: A: IOP ≤ 21 mmHg+IOP reduction ≥20% from baseline; B: IOP ≤ 18 mmHg+IOP reduction ≥20%; C: IOP ≤ 15 mmHg+IOP reduction ≥25%; D: IOP≤12 mmHg+IOP reduction ≥30%. Success was defined as qualified or complete based on whether reached with or without medication. Primary outcome was success according to the above criteria. Secondary outcomes included: IOP, best-corrected visual acuity (BCVA), medication use, complications, postoperative interventions, and failure-associated factors.Qualified and complete success rates (95% CI) at 12 months were 74%(66-83%) and 58%(49-69%) for criterion A, 72%(63-82%) and 57%(48-68%) for B, 52%(43-63%) and 47%(38-58%) for C, 29%(21-40%) and 26%(19-36%) for D. Overall median (interquartile range (IQR)) preoperative IOP decreased from 21.5(19-28) mmHg to 13(11-16) mmHg at 12 months. BCVA was not significantly different up to 12 months (p = 0.79). Preoperative median (IQR) number of medications decreased from 3 (2-3) to 0 (0-1) at 12 months. Twelve eyes underwent needling, five surgical revision and one device removal due to corneal oedema. There were no hypotony-related complications. Non-Caucasian ethnicity was the only risk factor consistently associated with increased failure.Preserflo™ Microshunt is a viable surgical option in glaucoma patients, with reasonable short-term success rates, decreased medications use, excellent safety profile, smooth postoperative care, and rapid learning curve. Success rates for the most stringent IOP cutoffs were modest, indicating that it may not be the optimal surgery when very low target IOP is required Bhayani, R., Martínez De La Casa Fernández-Borrella, J. M., Figus, M. et al. «Short-Term Safety and Efficacy of PreserfloTM Microshunt in Glaucoma Patients: A Multicentre Retrospective Cohort Study». Eye, vol. 37, n.o 4, marzo de 2023, pp. 644-49. DOI.org (Crossref), https://doi.org/10.1038/s41433-022-01995-7. 0950-222X 10.1038/s41433-022-01995-7 https://hdl.handle.net/20.500.14352/71372 https://doi.org/10.1038/s41433-022-01995-7 https://www.nature.com/articles/s41433-022-01995-7#citeas Short-term safety and efficacy of Preserflo™ Microshunt in glaucoma patients: a multicentre retrospective cohort study