2026-06-29T07:50:29Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/713862025-09-18T12:22:57Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Zabala Gutiérrez, Irene author Gerke, Christoph author Shen, Yingli author Ximendes, Erving Clayton author Manso Silvan, Miguel author Marin, Riccardo author Jaque García, Daniel author Gómez Calderón, Óscar author Melle Hernández, Sonia author Rubio Retama, Benito Jorge 2023-06-22T10:41:25Z 2023-06-22T10:41:25Z 2022 Zabala Gutiérrez, I., Gerke, C., Shen, Y. et al. «Boosting the Near-Infrared Emission of Ag 2 S Nanoparticles by a Controllable Surface Treatment for Bioimaging Applications». ACS Applied Materials & Interfaces, vol. 14, n.o 4, febrero de 2022, pp. 4871-81. DOI.org (Crossref), https://doi.org/10.1021/acsami.1c19344. 1944-8244 10.1021/acsami.1c19344 https://hdl.handle.net/20.500.14352/71386 https://doi.org/10.1021/acsami.1c19344 Ag2S nanoparticles are the staple for high-resolution preclinical imaging and sensing owing to their photochemical stability, low toxicity, and photoluminescence (PL) in the second near-infrared biological window. Unfortunately, Ag2S nanoparticles exhibit a low PL efficiency attributed to their defective surface chemistry, which curbs their translation into the clinics. To address this shortcoming, we present a simple methodology that allows to improve the PL quantum yield from 2 to 10%, which is accompanied by a PL lifetime lengthening from 0.7 to 3.8 μs. Elemental mapping and X-ray photoelectron spectroscopy indicate that the PL enhancement is related to the partial removal of sulfur atoms from the nanoparticle’s surface, reducing surface traps responsible for nonradiative de-excitation processes. This interpretation is further backed by theoretical modeling. The acquired knowledge about the nanoparticles’ surface chemistry is used to optimize the procedure to transfer the nanoparticles into aqueous media, obtaining water-dispersible Ag2S nanoparticles that maintain excellent PL properties. Finally, we compare the performance of these nanoparticles with other near-infrared luminescent probes in a set of in vitro and in vivo experiments, which demonstrates not only their cytocompatibility but also their superb optical properties when they are used in vivo, affording higher resolution images. eng Atribución 3.0 España Boosting the Near-Infrared Emission of Ag2S Nanoparticles by a Controllable Surface Treatment for Bioimaging Applications journal article URL https://docta.ucm.es/bitstreams/8b91abca-af0b-4621-93cd-6385b300b0d5/download File MD5 00d508d446a91ddcf601489419c9364c 6836832 application/pdf acsami.1c19344.pdf URL https://docta.ucm.es/bitstreams/11ca38a9-add4-46dd-88e3-7cc8ab3e374c/download File MD5 c17bf0a67e62dfe311c0339b4276e050 81023 text/plain acsami.1c19344.pdf.txt