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oai:docta.ucm.es:20.500.14352/713872024-09-02T13:20:30Zcom_20.500.14352_14col_20.500.14352_15

Lanthanide doped nanoheaters with reliable and absolute temperature feedback López Peña, Gabriel Hamraoui, Khouloud Horchan Naifer, Karima Gerke, Christoph Ortgies, Dirk H. Martín Rodríguez, Emma Chen, Guanying Jaque García, Daniel Rubio Retama, Benito Jorge The development of selective and controlled photo-thermal therapies requires luminescent nanoparticles capable of simultaneous heating and contactless thermal sensing. Until now, thermal therapies have suffered from a lack of control over the absolute temperature of the treated tissue because the nanothermometers used for thermal feedback, based on a spectral analysis of emitted radiation, were affected by the inhomogeneous extinction of the tissues. This work shows how this deficiency can be overcome by using core-shell-shell nanostructures doped with lanthanide ions (Nd3+ and Yb3+). Thermal reading was achieved from the analysis of the Yb3+ luminescence lifetime whereas simultaneous heating was achieved thanks to the non-radiative deexcitations of Nd3+ ions. Simple proof-of-concept experiments show the great potential of these lanthanide-doped nanostructures for the development of in vivo photo-thermal treatments with absolute and reliable thermal feedback. 2023-06-22T10:41:26Z 2023-06-22T10:41:26Z 2022-01-18 journal article López-Peña, G., Hamraoui, K. Horchan Naifer, K. et al. «Lanthanide Doped Nanoheaters with Reliable and Absolute Temperature Feedback». Physica B: Condensed Matter, vol. 631, abril de 2022, p. 413652. DOI.org (Crossref), https://doi.org/10.1016/j.physb.2021.413652. 09214526 10.1016/j.physb.2021.413652 https://hdl.handle.net/20.500.14352/71387 https://doi.org/10.1016/j.physb.2021.413652 eng NanoTBTech (801305); SPOT (895932) PID2019-106211RB-I00 and MAT2017-83111R RENIM-CM (S2017/BMD-3867) https://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Elsevier