2026-06-08T03:46:07Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/716172025-02-13T15:39:49Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Flores López, María author García Marchena, Nuria author Araos, Pedro author Requena Ocaña, Nerea author Porras Perales, Oscar author Torres Galván, Sandra author Suarez, Juan author Pizarro, Nieves author Torre, Rafael de la author Rubio, Gabriel author Ruiz Ruiz, Juan Jesús author Rodríguez De Fonseca, Fernando Antonio author Serrano, Antonia author Pavón Morón, Francisco Javier 2023-06-22T10:45:53Z 2023-06-22T10:45:53Z 2022 2076-3425 10.3390/brainsci12050588 https://hdl.handle.net/20.500.14352/71617 https://doi.org/10.3390/brainsci12050588 https://www.mdpi.com/2076-3425/12/5/588/htm Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs. eng Atribución 3.0 España Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders journal article URL https://docta.ucm.es/bitstreams/ffc946f9-2000-481d-b612-fe1de3dd4caf/download File MD5 a6c34c827a1d1d8009303cf1cb96b3e8 757974 application/pdf brainsci-12-00588-v2 (1).pdf URL https://docta.ucm.es/bitstreams/2f4a5d95-d0c4-4c09-954e-e3ac2443226a/download File MD5 c18e2b182afecd9608ae6ed3a2ba9916 66237 text/plain brainsci-12-00588-v2 (1).pdf.txt