2026-06-27T23:06:00Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/716372025-08-22T12:56:48Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author López De Andrés, Ana Isabel author Jiménez García, Rodrigo author Hernández Barrera, Valentín author Miguel Díez, Javier De author Miguel Yanes, José María De author Omaña Palanco, Ricardo author Carabantes Alarcón, David 2023-06-22T10:46:27Z 2023-06-22T10:46:27Z 2022 López De Andrés, A., Jiménez García, R., Hernández Barrera, V. et al. «Trends of Non-Traumatic Lower-Extremity Amputation and Type 2 Diabetes: Spain, 2001–2019». Journal of Clinical Medicine, vol. 11, n.o 5, febrero de 2022, p. 1246. https://doi.org/10.3390/jcm11051246. 2077-0383 10.3390/jcm11051246 https://hdl.handle.net/20.500.14352/71637 https://doi.org/10.3390/jcm11051246 https://www.mdpi.com/2077-0383/11/5/1246/htm Background: To examine trends in the incidence (2001–2019), clinical characteristics and in-hospital outcomes following major and minor non-traumatic lower-extremity amputations (LEAs) among people with type 2 diabetes mellitus (T2DM) in Spain, assessing possible sex differences. Methods: Retrospective cohort study using data from the Spanish National Hospital Discharge Database. Joinpoint regression was used to estimate incidence trends, and multivariable logistic regression to estimate factors associated with in-hospital mortality (IHM). Results: LEA was coded in 129,059 patients with T2DM (27.16% in women). Minor LEAs accounted for 59.72% of amputations, and major LEAs comprised 40.28%. The adjusted incidences of minor and major LEAs were higher in men than in women (IRR 3.51; 95%CI 3.46–3.57 and IRR 1.98; 95%CI 1.94–2.01, respectively). In women, joinpoint regression showed that age-adjusted incidence of minor LEAs remained stable over time, and for major LEAs, it decreased from 2006 to 2019. In men, incidences of minor and major LEAs decreased significantly from 2004 to 2019. In-hospital mortality (IHM) increased with age and the presence of comorbidity, such as heart failure (OR 5.11; 95%CI 4.61–5.68, for minor LEAs and OR 2.91; 95%CI 2.71–3.13 for major LEAs). Being a woman was associated with higher IHM after minor and major LEA (OR 1.3; 95%CI 1.17–1.44 and OR 1.18; 95%CI 1.11–1.26, respectively). Conclusions: Our data showed major sex differences indicating decreasing and increasing LEA trends among men and women, respectively; furthermore, women presented significantly higher IHM after minor and major LEA procedures than men. eng Atribución 3.0 España Trends of Non-Traumatic Lower-Extremity Amputation and Type 2 Diabetes: Spain, 2001–2019 journal article URL https://docta.ucm.es/bitstreams/d45a16c1-4343-4362-bd15-d094f71beeff/download File MD5 acbbe8e764314f86dd59a6a065e798b4 1350950 application/pdf jcm-11-01246.pdf