2026-06-27T22:49:49Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/718852024-10-24T11:36:52Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Pérez González, Fabián author Abusamak, Mohammad author Sáez Alcaide, Luis Miguel author Torres García Denche, Jesús author Marino, Faleh Ahmad Tamimi author 2022-08-03 Purpose: To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model. Methods: Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively. Results: Postoperative swelling and pain perception did not show signifcative diference between the control and experimental groups at 24, 48, and 72 h. Trismus was signifcantly lower in the control group than in the experimental group at 72 h postoperatively (p=0.008). Rescue medication consumption seemed to be comparable between groups. Conclusion: Eliminating night time ibuprofen might be insignifcant for pain control after third molar extraction. Pérez-González F, Abusamak M, Sáez-Alcaide LM, et al (2022) Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial. Oral Maxillofac Surg 27:699–706. https://doi.org/10.1007/s10006-022-01104-8 1865-1569 10.1007/s10006-022-01104-8 https://hdl.handle.net/20.500.14352/71885 https://doi.org/10.1007/s10006-022-01104-8 Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial