2026-06-27T10:22:07Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/721002025-05-23T17:47:45Zcom_20.500.14352_14col_20.500.14352_15

Arcos Navarrete, Daniel Gómez Cerezo, María Natividad Saiz-Pardo Sanz, Melchor Pablo Velasco, David De Ortega Medina, Luis Enciso, Silvia Fernández Tomé, Blanca Díaz Güemes, Idoia Sánchez Margallo, Francisco Miguel Casarrubios Palomar, Luis Feito Castellano, María José Portolés Pérez, María Teresa Vallet Regí, María Dulce Nombre 2023-06-22T11:05:50Z 2023-06-22T11:05:50Z 2022-08-03 1742-7061 10.1016/j.actbio.2022.07.067 https://hdl.handle.net/20.500.14352/72100 https://doi.org/10.1016/j.actbio.2022.07.067 The osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a high surface area and the ability to incorporate the anti-osteoporotic drug ipriflavone. In vitro expression of the pro-inflammatory genes NF-κB1, IL-6, TNF-α, P38 and NOS2 in RAW-264.7 macrophages, indicates that these nanoparticles do not show adverse inflammatory effects. An injectable system has been prepared by suspending MBNPs in a hyaluronic acid-based hydrogel, which has been injected intraosseously into cavitary bone defects in osteoporotic rabbits. The histological analyses evidenced that MBNPs promote bone regeneration with a moderate inflammatory response. The incorporation of ipriflavone into these nanoparticles resulted in a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation. eng https://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions journal article