2026-06-27T12:39:00Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/722352023-08-27T23:40:17Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Sanz Gomez, María
author
Zeng, Ni
author
Catagna Catagna, Gloria Estefania
author
Arribas Pardo, Paula
author
García Feijoo, Julián
author
Méndez Hernández, Carmen Dora
2023-06-22T11:14:13Z
2023-06-22T11:14:13Z
2023-02-06
2077-0383
10.3390/jcm12052071
https://hdl.handle.net/20.500.14352/72235
Background/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect of glaucoma disease on peripapillary vessel density (sPVD) and macular vessel density (sMVD) on the superficial vascular plexus, controlling differences on comorbidities such as SAH, DM and HC between glaucoma patients and normal subjects. Methods: In this prospective, unicenter, observational cross-sectional study, sPVD and sMVD were measured in 155 glaucoma patients and 162 normal subjects. Differences between normal subjects and glaucoma patients’ groups were analyzed. A linear regression model with 95% confidence and 80% statistical power was performed. Results: Parameters with greater effect on sPVD were glaucoma diagnosis, gender, pseudophakia and DM. Glaucoma patients had a sPVD 1.2% lower than healthy subjects (Beta slope 1.228; 95%CI 0.798–1.659, p < 0.0001). Women presented 1.19% more sPVD than men (Beta slope 1.190; 95%CI 0.750–1.631, p < 0.0001), and phakic patients presented 1.7% more sPVD than men (Beta slope 1.795; 95%CI 1.311–2.280, p < 0.0001). Furthermore, DM patients had 0.9% lower sPVD than non-diabetic patients (Beta slope 0.925; 95%CI 0.293–1.558, p = 0.004). SAH and HC did not affect most of the sPVD parameters. Patients with SAH and HC showed 1.5% lower sMVD in the outer circle than subjects without those comorbidities (Beta slope 1.513; 95%CI 0.216–2.858, p = 0.021 and 1.549; 95%CI 0.240–2.858, p = 0.022 respectively. Conclusions: Glaucoma diagnosis, previous cataract surgery, age and gender seem to have greater influence than the presence of SAH, DM and HC on sPVD and sMVD, particularly sPVD.
eng
Atribución 3.0 España
Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
journal article
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https://docta.ucm.es/bitstreams/07b6894b-9e34-4c8c-b5f1-452bfc1c9e40/download
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17c2cc587ace307a69e231192dc9b1ae
1272756
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jcm-12-02071.pdf
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https://docta.ucm.es/bitstreams/a3625947-26a2-4437-852f-2b094f87939f/download
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6e7ff57b75c9f7489a4de77335322c6f
67915
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jcm-12-02071.pdf.txt