2026-08-20T15:34:21Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/723442024-10-10T15:43:00Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Ortega, Miguel A. author Fraile Martínez, Oscar author García Montero, Cielo author Rodriguez Martín, Sonia author Funes Moñux, Rosa M. author Bravo Arribas, Coral author De Leon Luis, Juan A. author Saz, Jose V. author Saez, Miguel A. author Guijarro, Luis G. author Lahera, Guillermo author Monserrat Sanz, Jorge author Mora Mínguez, Fernando author Quintero Gutiérrez Del Álamo, Francisco Javier author Bujan, Julia author García Honduvilla, Natalio author Álvarez Mon, Melchor author Alvarez Mon, Miguel Ángel 2023-06-22T11:21:19Z 2023-06-22T11:21:19Z 2023 2076-3921 10.3390/antiox12010179 https://hdl.handle.net/20.500.14352/72344 https://doi.org/10.3390/antiox12010179 https://www.mdpi.com/journal/antioxidants Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and alterations in behavior and sensorial and motor functions. Although the onset of psychosis can be related to any medical condition, most cases of psychosis are not fully understood. Psychosis may manifest for the first time during pregnancy, which is detrimental to maternofetal well-being. The impact of having a first episode of psychosis during pregnancy on the placenta has not yet been explored. Oxidative stress is thought to take part in the etiopathogenesis of this complex disorder, and this condition can also affect the placenta as it is highly sensitive to changes in the maternal environment. In this sense, the aim of the present work was to study the gene and protein expression through RT–qPCR and immunohistochemistry, respectively, of oxidative stress markers (NOX-1, NOX-2, iNOS, eNOS and PARP) in the placental tissue of women who underwent a first episode of psychosis during pregnancy (FE-PW) in comparison to healthy pregnant women. Our results showed augmented gene and protein expression of NOX-1, NOX-2, iNOS and PARP in the placental tissue of FE-PW. For the first time, we demonstrated that oxidative stress may have an important pathophysiological role in this tissue, aiding in explaining the impact of psychosis on pregnancy and the need for future studies in this field to guide better clinical management of these patients. eng Atribución 3.0 España Evidence of Increased Oxidative Stress in the Placental Tissue of Women Who Suffered an Episode of Psychosis during Pregnancy journal article URL https://docta.ucm.es/bitstreams/80d983f7-a992-480b-bcd4-58de3ad23a52/download File MD5 593c2f2f957727dd9171c89eecaf1b86 2562104 application/pdf antioxidants-12-00179-v2.pdf URL https://docta.ucm.es/bitstreams/37c3051d-a2dc-4079-9bb8-b8ccf3631485/download File MD5 a4854eb5386e9e8c2a2aba43b329bb7a 62977 text/plain antioxidants-12-00179-v2.pdf.txt