2026-06-27T10:10:55Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/724542024-07-02T14:40:48Zcom_20.500.14352_14col_20.500.14352_15

Martínez Alberquilla, Irene Gasull, Xavier Pérez Luna, Patricia Seco Mera, Rubén Ruiz Alcocer, Javier Crooke Álvarez, Almudena 2023-06-22T12:26:32Z 2023-06-22T12:26:32Z 2021-12-28 Martínez-Alberquilla, I., Gasull, X., Pérez Luna, P. et al. «Neutrophils and Neutrophil Extracellular Trap Components: Emerging Biomarkers and Therapeutic Targets for Age-Related Eye Diseases». Ageing Research Reviews, vol. 74, febrero de 2022, p. 101553. DOI.org (Crossref), https://doi.org/10.1016/j.arr.2021.101553. 1568-1637 10.1016/j.arr.2021.101553 https://hdl.handle.net/20.500.14352/72454 https://doi.org/10.1016/j.arr.2021.101553 https://www.sciencedirect.com/science/article/pii/S1568163721003007?via%3Dihub Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy, represent a major global health issue based on their increasing prevalence and disabling action. Unraveling the molecular mechanisms underlying these diseases will provide novel opportunities to reduce the burden of age-related eye diseases and improve eye health, contributing to sustainable development goals achievement. The impairment of neutrophil extracellular traps formation/degradation processes seems to be one of these mechanisms. These traps formed by a meshwork of DNA and neutrophil cytosolic granule proteins may exacerbate the inflammatory response promoting chronic inflammation, a pivotal cause of age-related diseases.In this review, we describe current findings that suggest the role of neutrophils and their traps in the pathogenesis of the above-mentioned age-related eye diseases. Furthermore, we discuss why these cells and their constituents could be biomarkers and therapeutic targets for dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy. We also examine the therapeutic potential of some neutrophil function modulators and provide several recommendations for future research in age-related eye diseases eng https://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Neutrophils and neutrophil extracellular trap components: Emergingbiomarkers and therapeutic targets for age-related eye diseases journal article