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Neutrophils and neutrophil extracellular trap components: Emergingbiomarkers and therapeutic targets for age-related eye diseases Martínez Alberquilla, Irene Gasull, Xavier Pérez Luna, Patricia Seco Mera, Rubén Ruiz Alcocer, Javier Crooke Álvarez, Almudena 617.7‑007.681 617.7-053.6:612.112.91 612.112.91: 616-074 Neutrophil Neutrophil extracellular trap Dry eye Glaucoma Age-related macular degeneration Diabetic retinopathy Bioquímica (Medicina) Oftalmología Óptica fisiológica 3201.09 Oftalmología Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy, represent a major global health issue based on their increasing prevalence and disabling action. Unraveling the molecular mechanisms underlying these diseases will provide novel opportunities to reduce the burden of age-related eye diseases and improve eye health, contributing to sustainable development goals achievement. The impairment of neutrophil extracellular traps formation/degradation processes seems to be one of these mechanisms. These traps formed by a meshwork of DNA and neutrophil cytosolic granule proteins may exacerbate the inflammatory response promoting chronic inflammation, a pivotal cause of age-related diseases.In this review, we describe current findings that suggest the role of neutrophils and their traps in the pathogenesis of the above-mentioned age-related eye diseases. Furthermore, we discuss why these cells and their constituents could be biomarkers and therapeutic targets for dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy. We also examine the therapeutic potential of some neutrophil function modulators and provide several recommendations for future research in age-related eye diseases Instituto de Salud Carlos III Ministerio de Ciencia, Innovación y Universidades (España) Universidad de Barcelona Generalitat de Catalunya Universidad Complutense de Madrid - Banco de Santander Depto. de Optometría y Visión Unidad Docente de Bioquímica y Biología Molecular Fac. de Óptica y Optometría TRUE pub Received 14 September 2021; Received in revised form 17 November 2021; Accepted 23 December 2021; Available online 28 December 2021 2023-06-22T12:26:32Z 2023-06-22T12:26:32Z 2021-12-28 journal article https://hdl.handle.net/20.500.14352/72454 1568-1637 10.1016/j.arr.2021.101553 eng FIS P17/00296 and RETICs Oftared RD16/0008/0014 PID2020-119305RB-I00 MDM-2017-0729 2017SGR737 CT63/19-CT64/19 Martínez-Alberquilla, I., Gasull, X., Pérez Luna, P. et al. «Neutrophils and Neutrophil Extracellular Trap Components: Emerging Biomarkers and Therapeutic Targets for Age-Related Eye Diseases». Ageing Research Reviews, vol. 74, febrero de 2022, p. 101553. DOI.org (Crossref), https://doi.org/10.1016/j.arr.2021.101553. Atribución-NoComercial-SinDerivadas 3.0 España https://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access application/pdf Elsevier