2026-06-27T22:46:27Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/724642024-09-04T13:14:15Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Sola Vendrell, Emma author Moyano-Cires Ivanoff, Paula Viviana author Flores, Andrea author García Lobo, Jimena author García Sánchez, José Manuel author Anadón Baselga, María José author Frejo Moya, María Teresa author Pelayo Alarcón, Adela author Fernández Fernández, María De La Cabeza author Pino Sans, Javier Del 2023-06-22T12:26:37Z 2023-06-22T12:26:37Z 2021-12-28 Sola Vendrell, E., Moyano-Cires Ivanoff, P. V., Flores, A. et al. «Cadmium-Induced Neurotoxic Effects on Rat Basal Forebrain Cholinergic System through Thyroid Hormones Disruption». Environmental Toxicology and Pharmacology, vol. 90, febrero de 2022, p. 103791. DOI.org (Crossref), https://doi.org/10.1016/j.etap.2021.103791. 1382-6689 10.1016/j.etap.2021.103791 https://hdl.handle.net/20.500.14352/72464 https://doi.org/10.1016/j.etap.2021.103791 Cadmium (Cd) single and repeated exposure produces cognitive dysfunctions. Basal forebrain cholinergic neurons (BFCN) regulate cognitive functions. BFCN loss or cholinergic neurotransmission dysfunction leads to cognitive disabilities. Thyroid hormones (THs) maintain BFCN viability and functions, and Cd disrupts their levels. However, Cd-induced BFCN damages and THs disruption involvement was not studied. To research this we treated male Wistar rats intraperitoneally with Cd once (1 mg/kg) or repetitively for 28 days (0.1 mg/kg) with/without triiodothyronine (T3, 40 µg/kg/day). Cd increased thyroid-stimulating-hormone (TSH) and decreased T3 and tetraiodothyronine (T4). Cd altered cholinergic transmission and induced a more pronounced neurodegeneration on BFCN, mediated partially by THs reduction. Additionally, Cd antagonized muscarinic 1 receptor (M1R), overexpressed acetylcholinesterase S variant (AChE-S), downregulated AChE-R, M2R, M3R and M4R, and reduced AChE and choline acetyltransferase activities through THs disruption. These results may assist to discover cadmium mechanisms that induce cognitive disabilities, revealing a new possible therapeutic tool. eng Atribución-NoComercial-SinDerivadas 3.0 España Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption journal article URL https://docta.ucm.es/bitstreams/dcd5dcf4-d9a6-4299-88e9-5bd3266cd100/download File MD5 8921ad00fdf70039f3e9383fe5c45504 9191590 application/pdf 1-s2.0-S138266892100209X-main.pdf URL https://docta.ucm.es/bitstreams/2e5b546f-fd5c-453d-a29b-3321c169f889/download File MD5 670dfadcddd296754541c3a58d8fe98c 103408 text/plain 1-s2.0-S138266892100209X-main.pdf.txt